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dc.contributor.authorFarooq, Muhammad Umar
dc.contributor.authorSahin, Yesim Muge
dc.contributor.authorNaz, Muhammad Yasin
dc.contributor.authorIjaz, Salman
dc.contributor.authorShukrullah, Shazia
dc.contributor.authorMakhlouf, Mohamed M.
dc.date.accessioned2022-11-22T07:55:59Z
dc.date.available2022-11-22T07:55:59Z
dc.date.issued2022en_US
dc.identifier.citationVanaja, M., & Annadurai, G. (2013). Coleus aromaticus leaf extract mediated synthesis of silver nanoparticles and its bactericidal activity. Applied nanoscience, 3(3), 217-223.en_US
dc.identifier.issn2190-5509
dc.identifier.urihttps://doi.org/10.1007/s13204-022-02645-w
dc.identifier.urihttps://hdl.handle.net/20.500.12294/3054
dc.description.abstractA paradigm transition in cancer treatment gradually moved from "one drug-one target" toward "multi-target selective drugs design", because different drugs simultaneously inhibit tumor progression differently. The underlying mechanism has encountered significant challenges, such as encapsulating chemotherapies into a nanosized particulate system, adverse side effects, and managing multidrug-resistant. To address these issues, herein we engineered the gold nanoparticles’ surfaces with cross-linked polyethylene glycol that have well-controlled morphology and further encapsulated with commonly known chemo-drugs paclitaxel and bleomycin for nanovectorization of therapeutics to the intended site and there act through the concurrent action of dual targeting mechanisms without creating undesired side effects. The structures of the nanovectorization particulate system were confirmed by various spectroscopic techniques. The efficacy of nanovectorization particulate system and non-targeted free drugs was evaluated using the human cervical adenocarcinoma cell model. Our findings indicate that this nanovectorization particulate system had synergic stimuli-responsive characteristics and unrivaled control of efficient transportation of therapeutics agents. This system meets the high demand for multiple targeting delivery and has substantial benefits across multiple fields of nanomedicine, especially in chemotherapy. © 2022, King Abdulaziz City for Science and Technology.en_US
dc.language.isoengen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofApplied Nanoscience (Switzerland)en_US
dc.identifier.doi10.1007/s13204-022-02645-wen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCancer Therapyen_US
dc.subjectCervical Canceren_US
dc.subjectDual Targetingen_US
dc.subjectGold Nanoparticlesen_US
dc.subjectMetal Complexesen_US
dc.subjectNanomedicineen_US
dc.titleSurface engineered AuNPs for paclitaxel-loaded bleomycin delivery as a supplementation therapyen_US
dc.typearticleen_US
dc.departmentMühendislik ve Mimarlık Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.authorid0000-0003-2119-1216en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.institutionauthorSahin, Yesim Muge
dc.authorwosidGBZ-8749-2022en_US
dc.authorscopusid56583783200en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.wosWOS:000862514100001en_US
dc.identifier.scopus2-s2.0-85139212992en_US


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