https://hdl.handle.net/20.500.12294/1670 Research Outputs | TR-Dizin | WoS | Scopus | PubMed Sun, 26 Apr 2026 08:33:24 GMT 2026-04-26T08:33:24Z https://hdl.handle.net/20.500.12294/1157 Hisse senedi fiyatlarının açıklanmasında finansal oranların rolü : BİST sanayi endeksindeki firmalar örneği Özçelik, Tuğba H. ... Yüksek lisans tezi. Fri, 01 Jan 2016 00:00:00 GMT https://hdl.handle.net/20.500.12294/1157 2016-01-01T00:00:00Z https://hdl.handle.net/20.500.12294/4141 Energy Absorption of a Novel Lattice Structure-Filled Multicell Thin-Walled Tubes Under Axial and Oblique Loadings Kocabas, Gazi Basar; Yalcinkaya, Senai; Cetin, Erhan; Sahin, Yusuf Multicell design and lattice structure as filling material are two effective methods for enhancing the energy absorption performance of thin-walled tubes. This study combines these two approaches to present a multicell tube with a novel lattice structure and investigates the energy absorption performances of these hybrid multicell tubes under axial (0 degrees) and oblique (10 degrees, 20 degrees, and 30 degrees) impact loading conditions. As filling structure, beta-Ti3Au lattice geometry with varying lattice strut diameters and the number of lattice unit cells are used, while the single and multicell thin-walled tubes with different tube thicknesses are employed as main absorbing element. In this context, the effects of numbers of lattice unit cells, lattice strut diameter, cell numbers of the tube, and tube thickness on energy absorption performance of hybrid tubes are examined using validated nonlinear finite element models. This investigation unveils that the synergistic interplay between the multicell tubes and lattice structure during deformation significantly elevates the energy absorption performance of the hybrid structure. Notably, the findings demonstrate that multicell hybrid tubes exhibit a remarkable capacity to absorb up to 30.36% more impact energy compared to the aggregate absorption of individual components in hybrid tubes.This study introduces the beta-Ti3Au lattice structure as a novel filling material to enhance the energy absorption of thin-walled multicell tubes. It examines the effects of lattice unit cell numbers, lattice strut diameter, tube cell numbers, and tube thickness on energy absorption using validated nonlinear finite element models.image (c) 2024 WILEY-VCH GmbH Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/20.500.12294/4141 2024-01-01T00:00:00Z https://hdl.handle.net/20.500.12294/4140 RB1 gene mutations and genetic spectrum in retinoblastoma cases Odemis, Demet Akdeniz; Kebudi, Rejin; Bayramova, Jamila; Erciyas, Seda Kilic; Turkcan, Gozde Kuru; Tuncer, Seref Bugra; Erdogan, Ozge Sukruoglu; Celik, Betul; Gultaslar, Busra Kurt; Bay, Sema Buyukkapu; Tuncer, Samuray; Yazici, Hulya The aim of the study was to investigate the frequency and types of mutations on the retinoblastoma gene (RB1 gene) in Turkish population. RB1 gene mutation analysis was performed in a total of 219 individuals (122 probands with retinoblastoma, 14 family members with retinoblastoma and 83 clinically healthy family members). All 27 exons and close intronic regions of the RB1 gene were sequenced for small deletions and insertions using both the Sanger sequencing or NGS methods, and the large deletions and duplications were investigated using the MLPA analysis and CNV algorithm. The bilateral/trilateral retinoblastoma rate was 66% in the study population. The general frequency of RB1 gene mutation in the germline of the patients with retinoblastoma was 41.9%. Approximately 51.5% of the patients were diagnosed earlier than 12 months old, and de novo mutation was found in 32.4% of the patients. Germline small genetic rearrangement mutations were detected in 78.9% of patients and LGRs were detected in 21.1% of patients. An association was detected between the eye color of the RB patients and RB1 mutations. 8 of the mutations detected in the RB1 gene were novel in the study. Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/20.500.12294/4140 2024-01-01T00:00:00Z https://hdl.handle.net/20.500.12294/4139 Adsorption and desorption of hydroxychloroquine onto sulphur doped graphene powders as a potential drug for COVID-19 Acar, Tayfun; Arvas, Melih Besir; Arvas, Busra; Ucar, Burcu; Sahin, Yucel Hydroxychloroquine (HCQ) is a very substantial drug active substance that was approved for emergency use by the FDA during the peak of the COVID-19 pandemic due to its potent antiviral properties. In this study, adsorption and desorption of hydroxychloroquine on sulfur (S)-doped graphene powders were investigated. While the adsorption experiments were carried out in the environment of distilled water (pH 5.0-6.0), HEPES buffer (pH 7.6), and Tris.HCl buffer (pH 8.0) the desorption studies were performed in distilled water. The HCQ adsorbed S-doped graphene powders were characterized by UV-Vis, FT-IR, XRD, BET and TEM techniques. According to UV-Vis measurements, the adsorption efficiency in the HEPES buffer medium at pH 7.6 was the highest (68.72% for H3 (HCQ adsorption with SGr3 graphene in HEPES medium)). FT-IR and XRD analyses confirmed the presence of HCQ on the graphene powders' surface. While morphological changes on the surfaces of graphene powders were imaged by TEM, BET surface area changes proved the HCQ adsorption. The in vitro toxicity of the developed H3 was found to be lower than that of HCQ alone on the L929 cell line. These fundamental findings of the surface interaction between HCQ and graphene are precious for the design and optimization of a targeted drug based on this molecule and material. The adsorption/desorption features of HCQ onto graphene-based carrier systems which in particular doped with sulfur from functional metals have been investigated for the first time. Mon, 01 Jan 2024 00:00:00 GMT https://hdl.handle.net/20.500.12294/4139 2024-01-01T00:00:00Z