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Breast Cancer in East Africa: Prevalence and Spectrum of Germline SNV/Indel and CNVs in BRCA1 and BRCA2 Genes Among Breast Cancer Patients in Tanzania
(John Wiley and Sons Inc, 2022)
Background: Growing prevalence and aggressiveness of breast cancer (BC) among East African women strongly indicate that the genetic risk factor implicated in the etiology of the disease may have a key role. Germline ...
Manufacturing of emulsion type garlic paste
(John Wiley and Sons Inc, 2024)
The objective of this work was to investigate the steady, dynamic mechanical properties, and 3 interval thixotropy test (3 ITT) characterization of emulsion type garlic paste prepared with different concentrations of ...
Investigation of the methylation changes in the promoter region of RB1 gene in retinoblastoma
(Elsevier GmbH, 2024)
Retinoblastoma is an infrequent neoplasm that arises during childhood from retinal nerve cells and is attributed to the biallelic inactivation of the RB1 gene. In conjunction with anatomical anomalies, it is widely ...
Computational analysis of drug resistance of taxanes bound to human β-tubulin mutant (D26E)
(Elsevier Inc., 2023)
The single-point mutation D26E in human β-tubulin is associated with drug resistance seen with two anti-mitotic taxanes (paclitaxel and docetaxel) when used to treat cancers. The molecular mechanism of this resistance ...
2D Vector Representation of Binomial Hierarchical Tree Items
(Institute of Electrical and Electronics Engineers Inc., 2022)
Today Artificial Intelligence (AI) algorithms need to represent different kinds of input items in numeric or vector format. Some input data can easily be transformed to numeric or vector format but the structure of some ...
Chemical Characterization of Different Extracts from Artemisia annua and Their Antioxidant, Enzyme Inhibitory and Anti-Inflammatory Properties
(John Wiley and Sons Inc, 2023)
Artemisia annua L. (Asteraceae Family) is an important plant in Asia that has been used for treating different diseases, including fever due to malaria, wounds, tubercolisis, scabues, pain, convulsions, diabetes, and ...
Challenges experienced by pediatric nurses in the process of developing innovative products
(W.B. Saunders, 2024)
Objective: As essential healthcare providers, nurses are key to contributing innovations to improve the quality of care. This study aimed to explore the challenges pediatric nurses face in developing and patenting innovative ...
Modulation of Neuronal Damage in DRG by Asprosin in a High-Glucose Environment and Its Impact on miRNA181-a Expression in Diabetic DRG
(Springer, 2024)
Asprosin, a hormone secreted from adipose tissue, has been implicated in the modulation of cell viability. Current studies suggest that neurological impairments are increased in individuals with obesity-linked diabetes, ...
Antioxidant, enzyme inhibition, toxicity, and molecular docking analysis of Melaleuca cajuputi leaf extract and fractions
(Visagaa Publishing House, 2024)
Melaleuca cajuputi plant has piqued the interest of researchers due to its pharmacological properties. However, there is scarce information regarding its enzyme inhibitory effects and possible mechanism of action. Thus, ...
Implant-Based Breast Reconstruction with Bovine Pericardium
(Springer, 2023)
Objectives: To describe the usage and advantages of bovine pericardium mesh (Tutopatch®) in breast reconstruction and to compare different mesh materials used in immediate breast reconstruction. Methods: Our study involved ...