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Fabrication, characterization and fibroblast proliferative activity of electrospun Achillea lycaonica-loaded nanofibrous mats

dc.contributor.authorCam, Muhammet Eminen_US
dc.contributor.authorCesur, Sümeyyeen_US
dc.contributor.authorTaşkın, Turguten_US
dc.contributor.authorErdemir, Gökçeen_US
dc.contributor.authorKuruca, Dürdane Serapen_US
dc.contributor.authorŞahin, Yeşim Mügeen_US
dc.contributor.authorKabasakal, Leventen_US
dc.contributor.authorGündüz, Oğuzhanen_US
dc.date.accessioned2019-10-29T17:48:37Z
dc.date.available2019-10-29T17:48:37Z
dc.date.issued2019
dc.identifier.issn0014-3057
dc.identifier.urihttps://dx.doi.org/10.1016/j.eurpolymj.2019.109239
dc.identifier.urihttps://hdl.handle.net/20.500.12294/1881
dc.descriptionŞahin, Yeşim Müge (Arel Author)en_US
dc.description.abstractThe use of natural compounds such as biocompatible and non-toxic plant extracts, without undesired side effects, in tissue engineering applications, is highly preferred compared to chemical drugs. In this study, the characterization and performance of electrospun Achillea lycaonica-loaded (0.125, 0.250 and 0.500, wt%) poly(lactic acid) (PLA) (8%, w/v) nanofibrous mats for skin tissue engineering were investigated. SEM, FTIR, DSC, and tensile strength test of the electrospun nanofibers have been investigated. Drug releasing test and cell culture study were also carried out. Achillea lycaonica-loaded nanofibrous mats in 0.250 (wt%) and 0.500 (wt%) demonstrated excellent cell compatibility and increased the viability of NIH/3T3 (mouse embryo fibroblast) cells within 72 h. According to the results, Achillea lycaonica-loaded PLA nanofibers have proper tensile strength and controlled release. The working temperature range enlarged for the composites having higher plant extract content. Consequently, Achillea lycaonica-loaded nanofibrous mats have a great potential in skin tissue engineering applications. © 2019 Elsevier Ltden_US
dc.description.sponsorshipDr. Muhammet E. Cam was supported by a TUBITAK 2219 Research Programme Grant ( Scientific and Technological Research Council of Turkey -TUBITAK) and thanks UCL Mechanical Engineering for hosting his post-doctoral research in the UK.en_US
dc.language.isoengen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofEuropean Polymer Journalen_US
dc.identifier.doi10.1016/j.eurpolymj.2019.109239en_US
dc.identifier.doi10.1016/j.eurpolymj.2019.109239
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAchillea lycaonicaen_US
dc.subjectElectrospinningen_US
dc.subjectFibroblast proliferationen_US
dc.subjectNanofibersen_US
dc.subjectPolylactic aciden_US
dc.subjectSkin tissue engineeringen_US
dc.titleFabrication, characterization and fibroblast proliferative activity of electrospun Achillea lycaonica-loaded nanofibrous matsen_US
dc.typearticleen_US
dc.departmentİstanbul Arel Üniversitesi, Mühendislik-Mimarlık Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.identifier.volume120en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-tempCam, M.E., Center for Nanotechnology and Biomaterials Research, Marmara University, Istanbul, 34722, Turkey, Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, United Kingdom, Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul, 34668, Turkey; Cesur, S., Center for Nanotechnology and Biomaterials Research, Marmara University, Istanbul, 34722, Turkey, Department of Metallurgy and Material Engineering, Faculty of Technology, Marmara University, Istanbul, 34722, Turkey; Taskin, T., Department of Pharmacognosy, Faculty of Pharmacy, Marmara University, Istanbul, 34668, Turkey; Erdemir, G., Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, 34093, Turkey; Kuruca, D.S., Department of Physiology, Faculty of Medicine, Istanbul University, Istanbul, 34093, Turkey; Sahin, Y.M., Department of Biomedical Engineering, Faculty of Engineering and Architecture, Istanbul Arel University, Istanbul, 34537, Turkey, ArelPOTKAM (Polymer Technologies and Composite Application and Research Center), Istanbul Arel University, Istanbul, 34537, Turkey; Kabasakal, L., Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul, 34668, Turkey; Gunduz, O., Center for Nanotechnology and Biomaterials Research, Marmara University, Istanbul, 34722, Turkey, Department of Metallurgy and Material Engineering, Faculty of Technology, Marmara University, Istanbul, 34722, Turkeyen_US


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