Developments of 3D polycaprolactone/beta-tricalcium phosphate/collagen scaffolds for hard tissue engineering
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2019Author
Aydoğdu, M.O.Mutlu, B.
Kurt, M.
İnan, A.T.
Kuruca, S.E.
Erdemir, G.
Şahin, Yeşim Müge
Ekren, N.
Oktar, F.N.
Gündüz, O.
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3D bioprinting provides an innovative strategy to fabricate a new composite scaffold material consisted in a porous and rough structure with using polycaprolactone (PCL), beta-tricalcium phosphate (?-TCP), and collagen as a building block for tissue engineering. We investigated the optimization of the scaffold properties based on the ?-TCP concentration using 3D bioprinting method. Computer-aided drawing was applied in order to digitally design the scaffolds while instead of solid filaments, materials were prepared as a blend solution and controlled evaporation of the solvent during the bioprinting was enabled the proper solidification of the scaffolds, and they were successfully produced with well-defined porous structure. This work demonstrated the feasibility of complex PCL/?-TCP/collagen scaffolds as an alternative in the 3D bioprinting engineering to the fabrication of porous scaffolds for tissue engineering. © 2019, Australian Ceramic Society.