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A Review of Functional Characterization of Single Amino Acid Change Mutations in HNF Transcription Factors in MODY Pathogenesis

Çubuk, Hasan; Yalçın Çapan, Özlem (Springer, 2021)

Mutations in HNF transcription factor genes cause the most common subtypes of maturity-onset of diabetes of youth (MODY), a monogenic form of diabetes mellitus. Mutations in the HNF1-alpha, HNF4-alpha, and HNF1-beta genes ...

HNF1A-MODY Mutations in Nuclear Localization Signal Impair HNF1A-Import Receptor KPNA6 Interactions

Fareed, Fareed M. A.; Korulu, Şirin; Özbil, Mehmet; Çapan Yalçın, Özlem (Springer, 2021)

Mutations in hepatocyte nuclear factor (HNF)1A gene cause the most common form of Maturity-onset diabetes of the young (MODY), a monogenic subtype of diabetes mellitus. Functional characterization of mutant proteins reveals ...

p60-katanin: a novel interacting partner for p53

Korulu, Şirin; Yıldız, Ayşegül (Springer, 2020)

Katanin, one of the best-characterized microtubule (MT) severing proteins, is composed of two subunits: catalytic p60-katanin, and regulatory p80-katanin. p60-katanin triggers MT reorganization by severing them. MT ...

Gene therapy in haemophilia: literature review and regional perspectives for Turkey

Kavakli, Kaan; Antmen, Bulent; Okan, Vahap; Sahin, Fahri; Aytac, Selin; Balkan, Can; Berber, Ergul; Kaya, Zuhre; Kupesiz, Alphan; Zulfikar, Bulent (SAGE Publications Ltd, 2022)

Haemophilia is an X-linked lifelong congenital bleeding disorder that is caused by insufficient levels of factor VIII (FVIII; haemophilia A) or factor IX (FIX; haemophilia B) and characterized by spontaneous and trauma-related ...

Whole exome sequencing reveals novel candidate gene variants for MODY

Çapan Yalçın, Özlem; Aydın, Neslihan; Yılmaz, Temel; Berber, Ergül (Elsevier, 2020)

Maturity-onset diabetes of the young (MODY) is a monogenic subtype of diabetes mellitus. Although 14 genes were associated to different subtypes of MODY, 30-40% of MODY patients have unidentified genetic mutations. In this ...

Epigenetics in Bladder Cancer: A Review of the Literature

Doğan, Tunay; Yazıcı, Hülya (Kare Publishing, 2021)

Bladder cancer (BC) is the 10th most frequent type of cancer worldwide, with around 549.000 new cases and 200.000 deaths/year and it has the highest incidence rates with a strong male and elderly predominance. Besides, BC ...

Comparison of Clinically Approved Molecules on SARS-CoV-2 Drug Target proteins: A Molecular Docking Study

Çubuk, Hasan; Özbil, Mehmet (TUBITAK, 2021)

The new type of coronavirus, SARS-CoV-2 has affected more than 22.6 million people worldwide. Since the first day the virus was spotted in Wuhan, China, numerous drug design studies have been conducted all over the globe. ...

Synthesis, Characterization and Biocompatibility Oo Plant-Oil Based Hydrogels

Yalçın Çapan, Özlem; Çakır Hatır, Pınar (Trakya University, 2021)

Biocompatible hydrogels are used in a variety of biomedical applications, including tissue scaffolds, drug delivery systems, lab/organ-on-a-chips, biosensors, cell-culture studies and contact lenses. The demand for novel ...

Aktif Bölge Mimarisinin Anlaşılması Temelinde, NAD + Bağımlı Mutant Candida methylica Format Dehidrogenaz Enziminin Spesifik Aktivitesinin Arttırılması

Binay, Barış; Torun, Soner (TÜBİTAK KBAG Proje, 2023)

Format dehidrogenaz enzimi (FDH), endüstriyel biyokatalizörler arasında son yıllarda en çok dikkat çeken enzimlerden biridir. Özellikle NAD(P)+ bağımlı FDH, gerçekleştirdiği reaksiyonun düşük redoks potansiyeli nedeniyle ...

İnsan p60-katanin Proteininin, Bitki RIC1 ve İnsan Homoloğu Kiaa1432 Proteinleri ile Etkileşiminin Tespiti & Etkileşimin Mikrotubuller Üzerinde Fonksiyonel Analizi

Korulu, Şirin Koç; Selçuk, İlke; Kurtoğlu, Ceren (TÜBİTAK KBAG Proje, 2023)

Mikrotubuller ihtiyaç durumuna göre uzayıp–kısalabilen, yeniden organize olabilen dinamik yapılı polimerlerdir. Mikrotubul organizasyonu, bölünen hücrelerde mitoz, post-mitotik nöronlarda akson/dendrit yapılarının ...

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