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dc.contributor.authorBaş Kıray, Evrimen_US
dc.contributor.authorBülbül, Alien_US
dc.contributor.authorSirzai, Hülyaen_US
dc.contributor.authorArslan, Seldaen_US
dc.contributor.authorUslu, Sinanen_US
dc.contributor.authorBaş, Vedaten_US
dc.contributor.authorZubarioğlu, Umuten_US
dc.contributor.authorÇelik, Muhittinen_US
dc.contributor.authorDursun, Mesuten_US
dc.contributor.authorGüran, Ömeren_US
dc.contributor.authorKuran, Banuen_US
dc.identifier.citationBas, E. K., Bulbul, A., Sirzai, H., Arslan, S., Uslu, S., Bas, V., . . . Kuran, B. The long-term impacts of preterm birth and associated morbidities on bone health in preschool children: a prospective cross-sectional study from Turkey. Journal of Maternal-Fetal & Neonatal Medicine, 8. doi:10.1080/14767058.2020.1730801en_US
dc.description.abstractObjective: To evaluate the impact of preterm birth on bone health in preschool children. Methods: A total of 166 preschool children (aged 7-8 years) born preterm (n = 86, <37-week gestation) and at term (n = 80, >= 37 weeks of gestation) in our hospital were included in this prospective cross-sectional study. Data on antenatal, perinatal, and early postnatal characteristics and maternal obstetric history were obtained from medical records. Bone densitometry data including total bone mineral content (BMC), bone mineral density (BMD; total, lumbar, and femoral), z-scores, and bone loss were collected for each participant. Results: Current height, weight, and BMI values were significantly lower in the preterm group (p < .001). Serum calcium, phosphorus and alkaline phosphatase (ALP) levels did not differ among groups, whereas VitD3 levels were significantly higher in the preterm group (p = .039). The mean total BMC, total BMD, lumbar (L2-L4) BMD, femur BMD, total z-score, and L2-L4 z-score values were significantly lower for the preterm group, whereas the total, lumbar, and femoral bone loss were significantly higher (p < .001), regardless of the severity of prematurity. Intraventricular hemorrhage (IVH) and retinopathy were significantly associated with lower total BMC (p = .004, p = .012, respectively). Fortified breastfeeding was associated with lumbar bone loss (p = .043), and formula feeding was associated with both femur and lumbar bone loss (p = .006, p = .012, respectively). Conclusions: Our findings revealed long-term adverse effects of preterm birth on bone health, with significantly lower anthropometric values (weight, height, and BMI), lower scores for total BMC, BMD (total, lumbar, femoral), and z-scores (total, femur), along with higher bone loss (total, lumbar, femoral) and higher rates of osteopenia and osteoporosis in preschool children born preterm (whether moderate or very preterm) compared with those born at term. Exclusive breastfeeding appears to reduce the likelihood of long-term bone loss in preterm infantsen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.subjectBone Mineral Contenten_US
dc.subjectBone Mineral Densityen_US
dc.subjectEarly-Life Factorsen_US
dc.subjectLong-Term Bone Healthen_US
dc.subjectPreschool Childrenen_US
dc.titleThe long-term impacts of preterm birth and associated morbidities on bone health in preschool children: a prospective cross-sectional study from Turkeyen_US
dc.departmentSağlık Bilimleri Yüksekokulu, Çocuk Gelişimi Bölümüen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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