Temel Tıp Bilimleri Bölümü Makale Koleksiyonu
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Subcortical Volume Changes in Schizophrenia and Bipolar Disorder: A Quantitative MRI Study
(Universidad de la Frontera, 2024)Volume abnormalities in subcortical structures, including the hippocampus, amygdala, thalamus, caudate, putamen, and globus pallidus have been observed in schizophrenia (SZ) and bipolar disorder (BD), not all individuals ... -
Aberrant miR-3135b and miR-1273g-3p expression in the peripheral blood samples of BRCA1/2 (±) ovarian cancer patients
(Elsevier Ltd, 2024)Ovarian cancer (OC) ranks as the eighth most prevalent malignancy among women globally. The short non-coding RNA molecules, microRNAs (miRNAs) target multiple mRNAs and regulate the gene expression. Here in this study, we ... -
Germline mutational variants of Turkish ovarian cancer patients suspected of Hereditary Breast and Ovarian Cancer (HBOC) by next-generation sequencing
(Elsevier GmbH, 2024)Hereditary Breast and Ovarian Cancer (HBOC) syndrome is characterized by an increased risk of developing breast cancer (BC) and ovarian cancer (OC) due to inherited genetic mutations. Understanding the genetic variants ... -
Structural and Functional Changes in the Brains of Guitarist Musicians: Volumetric, VBM, and Resting State fMRI Study
(ERCIYES UNIV SCH MEDICINE, 2024)Objective: Musicians acquire intricate motor and auditory skills from an early age, serving as an exemplary model for brain plasticity. This study aimed to investigate the structural and functional differences in the brains ... -
Modulation of Neuronal Damage in DRG by Asprosin in a High-Glucose Environment and Its Impact on miRNA181-a Expression in Diabetic DRG
(Springer, 2024)Asprosin, a hormone secreted from adipose tissue, has been implicated in the modulation of cell viability. Current studies suggest that neurological impairments are increased in individuals with obesity-linked diabetes, ... -
Investigation of the methylation changes in the promoter region of RB1 gene in retinoblastoma
(Elsevier GmbH, 2024)Retinoblastoma is an infrequent neoplasm that arises during childhood from retinal nerve cells and is attributed to the biallelic inactivation of the RB1 gene. In conjunction with anatomical anomalies, it is widely ... -
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker on oxidative stress and metabolism of elements in kidney of STZ-induced diabetic rats
(Academic Press Inc., 2024)In diabetes, increased oxidative stress and impaired trace element metabolism play an important role in the pathogenesis of diabetic nephropathy. The objective of this research was to examine the outcomes of blocking the ... -
DNA methylation of KIFC1 gene in determination of histological diagnosis, prognosis and metastasis of lung cancer
(ELSEVIER GMBH, 2023)Background: One of the main features of cancer, especially lung cancer (LC), is abnormal cell division. Abnormal expression of kinesin family member C1 (KIFC1/HSET), which is involved in mitotic cell division and ensures ... -
RB1 gene mutations and genetic spectrum in retinoblastoma cases
(LIPPINCOTT WILLIAMS & WILKINS, 2023)The aim of the study was to investigate the frequency and types of mutations on the retinoblastoma gene (RB1 gene) in Turkish population. RB1 gene mutation analysis was performed in a total of 219 individuals (122 probands ... -
Evaluating the brainstem in children with breathholding spells
(Kare Publishing, 2022)OBJECTIVE: Breath-holding spells (BHSs) are a non-epileptic paroxysmal phenomenon characterized by frequent apnea episodes, loss of consciousness, and changes in skin tone and postural tone triggered by negative stimuli ... -
Histopathological View of Benign Essential Blepharospasm: Orbicularis Oculi Hormone Receptor Levels
(Kare Publishing, 2023)Objectives: Benign essential blepharospasm (BEB) is a focal dystonia characterized by involuntary contractions of the orbicularis oculi and periocular muscles. We aimed to investigate the effects of muscle receptor levels ... -
P323L Mutation in a Case with Prolonged SARS-CoV-2 PCR Positivity
(NLM (Medline), 2023)Coronavirus disease-2019 (COVID-19) emerged in the last months of 2019 and caused a pandemic effecting the whole world. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 has ... -
Tuberous Sclerosis Complex and Cancer
(KARE PUBL, 2023)Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome that can affect multiple organ systems such as the brain, heart, and lung, and neurological disorders such as autism spectrum disorder and mental retardation ... -
Examination of Brain-Derived Neurotrophic Factor, Glial Cell Line-Derived Neurotrophic Factor, and Neurotrophin-3 Levels and Brain Volumes in Shift-Working Men: Clinical Research
(Turkiye Klinikleri, 2023)Objective: This study aims to examine the levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and neurotrophin-3 (NT-3) and brain volumes in shift-working men. Material ... -
Impact of Cerebral Microbleeds in Stroke Patients with Atrial Fibrillation
(John Wiley and Sons Inc, 2023)Objectives: Cerebral microbleeds are associated with the risks of ischemic stroke and intracranial hemorrhage, causing clinical dilemmas for antithrombotic treatment decisions. We aimed to evaluate the risks of intracranial ... -
Can the Gut Microbiota Serve as a Guide to the Diagnosis and Treatment of Childhood Epilepsy?
(Elsevier Inc., 2023)Background: To investigate the activity of the gut-brain axis in the pathogenesis of childhood epilepsy and to define biomarkers capable of assisting with determining new strategies in that context. Methods: Twenty children ... -
Acute sleep deprivation: impairment of biventricular function assesed by speckle tracking echocardiography in healthy subjects
(SPRINGER HEIDELBERG, 2023)ObjectivesSleep deprivation (SD) has been found to be associated with an increased incidence of adverse cardiovascular disease (CVD) events. The aim of this study was to investigate whether or not acute SD has a pathological ... -
SARKOM PATOGENEZİNDE ETKİLİ OLABİLECEK YENİ ADAY GENLERİN ARAŞTIRILMASI
(İstanbul Üniversitesi, 2023)Amaç: Nükleer tıpta radyonüklit tedavilerde çalışan radyasyon görevlilerinin uzun dönemde maruz kaldığı radyasyon dozlarının belirlenmesi ve rutin olarak yapılan her bir tedavi prosedürünün bu dozlara katkısının belirlenmesi ... -
Stroke Risk and Antithrombotic Treatment During Follow-up of Patients With Ischemic Stroke and Cortical Superficial Siderosis
(LIPPINCOTT WILLIAMS & WILKINS, 2023)Background and ObjectivesIn patients with ischemic stroke (IS) or transient ischemic attack (TIA) and cortical superficial siderosis (cSS), there are few data regarding the risk of future cerebrovascular events and also ... -
Lactobacillus GG is associated with mucin genes expressions in type 2 diabetes mellitus: a randomized, placebo-controlled trial
(SPRINGER HEIDELBERG, 2023)Purpose Recent studies indicate that dysbiosis of gut microbiota and low-grade infammation are important pathogenic determinants of type two diabetes mellitus (T2DM). The aim of this study is to investigate the efects of ...