Advanced Search

Show simple item record

dc.contributor.authorYalçın Çapan, Özlemen_US
dc.contributor.authorÇakır Hatır, Pınaren_US
dc.date.accessioned2021-11-16T15:30:45Z
dc.date.available2021-11-16T15:30:45Z
dc.date.issued2021en_US
dc.identifier.citationÇAPAN, Ö. Y., & HATİR, P. C. (2021). SYNTHESIS, CHARACTERIZATION AND BIOCOMPATIBILITY OF PLANT-OIL BASED HYDROGELS. Trakya University Journal of Natural Sciences.en_US
dc.identifier.issn2147-0294
dc.identifier.issn2528-9691
dc.identifier.urihttps://doi.org/10.23902/trkjnat.925742
dc.identifier.urihttps://hdl.handle.net/20.500.12294/2888
dc.description.abstractBiocompatible hydrogels are used in a variety of biomedical applications, including tissue scaffolds, drug delivery systems, lab/organ-on-a-chips, biosensors, cell-culture studies and contact lenses. The demand for novel and functional monomers to be used in hydrogel synthesis is increasing as the number of biomedical applications and need for biomaterials increase. The purpose of the study was to develop novel hydrogels from renewable materials. Acrylated methyl ricinoleate, a plant oil-based monomer, was used as the renewable material. The effects of acrylated methyl ricinoleate/N-isopropyl acrylamide molar ratio on hydrogel structural properties, thermal stability and in vitro cytotoxicity were studied. FTIR spectroscopy was used to characterize the structural properties of the hydrogels, while TGA was used to characterize the thermal properties. HEK293 and Cos-7 cell lines were used to test the cytotoxicity of the monomers and hydrogels. IC50 values for acrylated methyl ricinoleate and N-isopropyl acrylamide were found to be greater than 25 mg/mL. Cell viability of hydrogels containing 50% or more acrylated methyl ricinoleate was greater than 60%, while hydrogel biocompatibility decreased with decreasing molar ratio of acrylated methyl ricinoleate. Cells showed a minimum viability of 80% when incubated in hydrogel degradation products. An environmentally friendly synthesis method was developed and novel biocompatible hydrogels from renewable materials were produced for biomedical applications.en_US
dc.language.isoengen_US
dc.publisherTrakya Universityen_US
dc.relation.ispartofTrakya University Journal of Natural Sciencesen_US
dc.identifier.doi10.23902/trkjnat.925742en_US
dc.identifier.doi10.23902/trkjnat.925742
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHydrogelen_US
dc.subjectRenewable Resourcesen_US
dc.subjectBiocompatibilityen_US
dc.subjectAcrylated Methyl Ricinoleateen_US
dc.titleSynthesis, Characterization and Biocompatibility Oo Plant-Oil Based Hydrogelsen_US
dc.typearticleen_US
dc.departmentFen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.authorid0000-0002-7511-3355en_US
dc.identifier.volume22en_US
dc.identifier.issue2en_US
dc.identifier.startpage147en_US
dc.identifier.endpage154en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record