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dc.contributor.authorAcer, Niyazien_US
dc.contributor.authorÖz, Fatmaen_US
dc.contributor.authorCeviz, Yasinen_US
dc.contributor.authorEröz, Recepen_US
dc.contributor.authorCanatan, Haliten_US
dc.contributor.authorYücekaya, Bircanen_US
dc.identifier.citationÖz, F., Acer, N., Ceviz, Y., Eröz, R., Canatan, H. & Yücekaya, B. (2021). Volumetric analysis of the brain structures of children with down's syndrome: A 3D MRI study. Journal of Experimental & Clinical Medicine, 38(2).en_US
dc.description.abstractDown’s syndrome (DS) is one of the most common genetic causes of mental and cognitive retardation. In fact, it results in a number of characteristic neuropsychological and physical symptoms, including mental retardation. The aim of this study was to compare the brain structure volumes of children with DS to those of healthy children using MRI Studio in order to investigate whether there exists correlation between the developmental stages of DS and the results of both the Denver II Developmental Screening Test and magnetic resonance imaging (MRI) quantitative analysis. Five children diagnosed with Down’s syndrome (age range = 2–6 years) were matched for gender and age with five healthy comparison subjects. To analyse the overall and regional brain volumes, high-resolution MRI scans were performed and a morphometric analysis was conducted via MRI Studio software. The MRI T1 volumetric images were normalised using a linear transformation, which was followed by large deformation diffeomorphic metric mapping. Significant decreases (p<0.05) in the volumes of the right pons, cerebellum and left superior frontal gyrus (prefrontal cortex) were observed in the children with DS when compared with the control group (p<0.05). Although decreases were detected in the regional volumes of other brain locations, they were not significant (p>0.05). It was further found that the developmental retardation observed in the children with DS, as detected using the Denver II test, increased due to decreases in the volumes of certain regions of the brain, although this was also not statistically significant (p>0.05). The results of this study generally confirm the findings of prior studies concerning the overall patterns of the brain volumes in children with DS and also provide new evidence of the abnormal volumes of specific regional tissue components among such a population. These results suggest that the brain volume reduction associated with DS may primarily be due to early developmental differences rather than neurodegenerative changes.en_US
dc.publisherOndokuz Mayis Universitesien_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.subjectBrain Volumeen_US
dc.subjectDenver II Testen_US
dc.subjectDown’s Syndromeen_US
dc.titleVolumetric Analysis of the Brain Structures of Children with Down’s Syndrome: A 3D MRI Studyen_US
dc.departmentTıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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